Transcription factors with Perturb-seq knockdown data for ENSG00000231863. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000231863 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000231863, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:160,765,228–160,765,951 | 165.5 kb | Distal (>10kb) Multiome | 63 | |
| chr6:160,766,832–160,767,914 | 163.6 kb | Distal (>10kb) Multiome | 438 | |
| chr6:160,882,741–160,883,759 | 48.0 kb | Distal (>10kb) Multiome | 224 | |
| chr6:160,930,570–160,931,847 | 103 bp | At TSS Multiome | 424 | |
| chr6:160,932,951–160,933,887 | 2.4 kb | Proximal (<10kb) Multiome | 76 | |
| chr6:160,973,120–160,974,206 | 42.5 kb | Distal (>10kb) Multiome | 262 | |
| chr6:160,975,941–160,976,668 | 45.2 kb | Distal (>10kb) Multiome | 101 | |
| chr6:160,991,139–160,992,602 | 60.5 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the ENSG00000231863 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.