Transcription factors with Perturb-seq knockdown data for ENSG00000230805. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000230805 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000230805, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:100,830,747–100,832,118 | 246.9 kb | Distal (>10kb) Multiome | 99 | |
| chr14:100,832,252–100,832,872 | 245.2 kb | Distal (>10kb) Multiome | 73 | |
| chr14:100,904,412–100,905,040 | 173.0 kb | Distal (>10kb) Multiome HiCAR | 121 | |
| chr14:101,073,182–101,073,652 | 4.0 kb | Proximal (<10kb) | 473 | |
| chr14:101,077,411–101,078,024 | 6 bp | At TSS Multiome | 165 | |
| chr14:101,083,887–101,084,072 | 6.2 kb | Proximal (<10kb) | 93 | |
| chr14:101,094,952–101,095,754 | 17.5 kb | Distal (>10kb) Multiome | 13 | |
| chr14:101,096,646–101,097,743 | 19.8 kb | Distal (>10kb) Multiome | 173 | |
| chr14:101,098,281–101,099,263 | 21.2 kb | Distal (>10kb) Multiome | 94 | |
| chr14:101,131,025–101,132,452 | 54.0 kb | Distal (>10kb) Multiome | 135 | |
| chr14:101,183,321–101,183,789 | 105.8 kb | Distal (>10kb) Multiome | 167 | |
| chr14:101,310,915–101,311,513 | 233.5 kb | Distal (>10kb) Multiome | 8 |
Genomic view of the ENSG00000230805 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.