Transcription factors with Perturb-seq knockdown data for ENSG00000229321. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000229321 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000229321, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:206,611,577–206,612,198 | 186.5 kb | Distal (>10kb) Multiome | 113 | |
| chr2:206,641,860–206,642,929 | 155.8 kb | Distal (>10kb) Multiome | 253 | |
| chr2:206,764,811–206,766,089 | 32.9 kb | Distal (>10kb) Multiome | 844 | |
| chr2:206,800,420–206,801,006 | 2.1 kb | Proximal (<10kb) | 166 | |
| chr2:206,803,033–206,803,913 | 4.7 kb | Proximal (<10kb) | 52 | |
| chr2:206,954,806–206,955,846 | 157.0 kb | Distal (>10kb) Multiome | 169 | |
| chr2:207,093,267–207,093,735 | 294.9 kb | Distal (>10kb) Multiome | 65 | |
| chr2:207,473,001–207,473,846 | 675.1 kb | Distal (>10kb) Multiome HiCAR | 203 | |
| chr2:207,528,862–207,530,966 | 731.5 kb | Distal (>10kb) Multiome HiCAR | 969 |
Genomic view of the ENSG00000229321 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.