Transcription factors with Perturb-seq knockdown data for ENSG00000228863. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000228863 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000228863, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,399,764–160,401,441 | 273.1 kb | Distal (>10kb) Multiome HiCAR | 590 | |
| chr1:160,539,925–160,540,644 | 133.2 kb | Distal (>10kb) Multiome | 479 | |
| chr1:160,619,659–160,620,443 | 53.4 kb | Distal (>10kb) Multiome | 187 | |
| chr1:160,651,647–160,653,226 | 21.0 kb | Distal (>10kb) Multiome | 296 | |
| chr1:160,658,117–160,659,135 | 15.0 kb | Distal (>10kb) Multiome | 111 | |
| chr1:160,665,307–160,666,295 | 7.8 kb | Proximal (<10kb) Multiome | 417 | |
| chr1:160,671,801–160,672,782 | 738 bp | At TSS | 95 | |
| chr1:160,673,361–160,673,557 | at TSS | At TSS | 77 | |
| chr1:160,674,985–160,675,879 | 2.1 kb | Proximal (<10kb) Multiome | 258 | |
| chr1:160,681,274–160,681,823 | 8.1 kb | Proximal (<10kb) Multiome | 237 | |
| chr1:160,910,331–160,911,177 | 237.2 kb | Distal (>10kb) Multiome | 97 | |
| chr1:160,947,055–160,947,669 | 273.9 kb | Distal (>10kb) Multiome | 35 | |
| chr1:160,948,561–160,949,851 | 275.9 kb | Distal (>10kb) Multiome | 173 |
Genomic view of the ENSG00000228863 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.