Transcription factors with Perturb-seq knockdown data for ENSG00000227107. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227107 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227107, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:237,603,751–237,604,242 | 8.7 kb | Proximal (<10kb) | 230 | |
| chr2:237,605,001–237,605,244 | 7.7 kb | Proximal (<10kb) | 123 | |
| chr2:237,608,512–237,608,833 | 4.1 kb | Proximal (<10kb) | 28 | |
| chr2:237,612,384–237,612,771 | 205 bp | At TSS | 25 | |
| chr2:237,613,797–237,614,051 | 820 bp | At TSS | 79 | |
| chr2:237,614,157–237,614,906 | 1.2 kb | Proximal (<10kb) | 629 | |
| chr2:237,615,920–237,616,550 | 2.9 kb | Proximal (<10kb) | 59 |
Genomic view of the ENSG00000227107 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.