Transcription factors with Perturb-seq knockdown data for ENSG00000226824. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226824 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226824, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:66,413,302–66,414,074 | 240.8 kb | Distal (>10kb) Multiome | 440 | |
| chr7:66,493,259–66,494,185 | 160.9 kb | Distal (>10kb) Multiome | 849 | |
| chr7:66,591,768–66,593,058 | 62.1 kb | Distal (>10kb) Multiome | 849 | |
| chr7:66,627,961–66,629,582 | 25.7 kb | Distal (>10kb) Multiome | 896 | |
| chr7:66,654,134–66,655,326 | 2 bp | At TSS Multiome | 1021 | |
| chr7:66,681,738–66,682,647 | 27.6 kb | Distal (>10kb) Multiome | 840 | |
| chr7:66,740,305–66,741,524 | 86.1 kb | Distal (>10kb) Multiome | 898 | |
| chr7:66,844,266–66,845,342 | 190.4 kb | Distal (>10kb) Multiome | 851 | |
| chr7:66,920,765–66,921,508 | 266.6 kb | Distal (>10kb) Multiome | 957 |
Genomic view of the ENSG00000226824 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.