Transcription factors with Perturb-seq knockdown data for ENSG00000226471. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226471 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226471, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:28,679,491–28,680,261 | 120.8 kb | Distal (>10kb) Multiome | 374 | |
| chr22:28,741,336–28,742,751 | 58.8 kb | Distal (>10kb) Multiome | 926 | |
| chr22:28,772,518–28,773,373 | 27.9 kb | Distal (>10kb) Multiome | 796 | |
| chr22:28,800,006–28,801,035 | 82 bp | At TSS Multiome | 829 | |
| chr22:28,882,670–28,884,893 | 82.7 kb | Distal (>10kb) Multiome | 802 | |
| chr22:29,004,535–29,005,249 | 204.2 kb | Distal (>10kb) Multiome | 417 | |
| chr22:29,029,712–29,031,115 | 230.2 kb | Distal (>10kb) Multiome | 773 | |
| chr22:29,071,484–29,071,874 | 270.9 kb | Distal (>10kb) Multiome | 332 | |
| chr22:29,072,494–29,074,480 | 272.2 kb | Distal (>10kb) Multiome | 537 |
Genomic view of the ENSG00000226471 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.