Transcription factors with Perturb-seq knockdown data for ENSG00000226398. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226398 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226398, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:42,025,109–42,025,522 | at TSS | At TSS | 202 | |
| chr2:42,030,111–42,030,531 | 4.8 kb | Proximal (<10kb) | 92 | |
| chr2:42,032,306–42,032,596 | 7.0 kb | Proximal (<10kb) | 30 | |
| chr2:42,035,251–42,035,491 | 9.9 kb | Proximal (<10kb) | 21 |
Genomic view of the ENSG00000226398 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.