Transcription factors with Perturb-seq knockdown data for ENSG00000224789. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000224789 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000224789, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,996,816–119,997,661 | 219.3 kb | Distal (>10kb) Multiome | 20 | |
| chr2:120,012,388–120,013,831 | 203.5 kb | Distal (>10kb) Multiome | 973 | |
| chr2:120,206,338–120,206,568 | 10.0 kb | Proximal (<10kb) | 149 | |
| chr2:120,216,352–120,216,602 | at TSS | At TSS | 106 | |
| chr2:120,222,919–120,223,954 | 6.9 kb | Proximal (<10kb) Multiome | 806 | |
| chr2:120,237,598–120,238,948 | 21.6 kb | Distal (>10kb) Multiome | 425 | |
| chr2:120,252,124–120,253,825 | 36.2 kb | Distal (>10kb) Multiome | 912 | |
| chr2:120,343,217–120,343,961 | 127.0 kb | Distal (>10kb) Multiome | 453 | |
| chr2:120,441,791–120,443,631 | 226.6 kb | Distal (>10kb) Multiome | 511 | |
| chr2:120,465,595–120,466,904 | 249.8 kb | Distal (>10kb) Multiome | 829 |
Genomic view of the ENSG00000224789 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.