Transcription factors with Perturb-seq knockdown data for ENSG00000213963. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000213963 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000213963, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:177,211,967–177,213,482 | 180.1 kb | Distal (>10kb) Multiome | 1144 | |
| chr2:177,263,465–177,265,584 | 127.8 kb | Distal (>10kb) Multiome | 1275 | |
| chr2:177,284,272–177,285,351 | 108.0 kb | Distal (>10kb) Multiome | 132 | |
| chr2:177,310,707–177,311,501 | 81.6 kb | Distal (>10kb) Multiome | 84 | |
| chr2:177,392,346–177,393,257 | 50 bp | At TSS Multiome | 1012 | |
| chr2:177,394,330–177,394,724 | 1.6 kb | Proximal (<10kb) | 214 | |
| chr2:177,478,776–177,479,348 | 86.4 kb | Distal (>10kb) Multiome | 41 | |
| chr2:177,535,764–177,536,624 | 143.5 kb | Distal (>10kb) Multiome | 160 | |
| chr2:177,552,350–177,553,389 | 160.2 kb | Distal (>10kb) Multiome | 825 | |
| chr2:177,618,280–177,619,321 | 226.1 kb | Distal (>10kb) Multiome | 849 | |
| chr2:177,681,932–177,682,409 | 289.4 kb | Distal (>10kb) Multiome | 64 |
Genomic view of the ENSG00000213963 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.