Transcription factors with Perturb-seq knockdown data for ENSG00000203325. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000203325 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000203325, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,776,109–31,776,832 | 296.9 kb | Distal (>10kb) Multiome | 86 | |
| chr1:31,788,126–31,789,694 | 284.8 kb | Distal (>10kb) Multiome | 713 | |
| chr1:31,815,736–31,816,251 | 257.4 kb | Distal (>10kb) Multiome | 666 | |
| chr1:31,937,587–31,938,944 | 135.0 kb | Distal (>10kb) Multiome | 1111 | |
| chr1:31,943,994–31,945,090 | 128.9 kb | Distal (>10kb) Multiome | 826 | |
| chr1:31,954,721–31,955,545 | 118.3 kb | Distal (>10kb) Multiome | 628 | |
| chr1:31,964,141–31,964,595 | 109.2 kb | Distal (>10kb) Multiome | 529 | |
| chr1:32,013,168–32,015,085 | 59.8 kb | Distal (>10kb) Multiome | 988 | |
| chr1:32,072,319–32,073,738 | 301 bp | At TSS Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 34.6 kb | Distal (>10kb) Multiome | 779 | |
| chr1:32,179,263–32,180,190 | 106.3 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:32,200,233–32,201,756 | 127.2 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 132.1 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,221,877–32,222,889 | 148.9 kb | Distal (>10kb) Multiome | 755 | |
| chr1:32,239,728–32,240,979 | 166.9 kb | Distal (>10kb) Multiome | 456 | |
| chr1:32,248,081–32,248,895 | 175.0 kb | Distal (>10kb) Multiome | 622 | |
| chr1:32,291,710–32,292,726 | 218.6 kb | Distal (>10kb) Multiome | 900 | |
| chr1:32,334,713–32,336,836 | 262.8 kb | Distal (>10kb) Multiome | 804 | |
| chr1:32,351,055–32,352,355 | 278.0 kb | Distal (>10kb) Multiome | 944 | |
| chr1:32,361,365–32,362,459 | 288.7 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the ENSG00000203325 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.