The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for ENPP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENPP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENPP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:119,415,758–119,417,536 | 256.6 kb | Distal (>10kb) Multiome | 611 | |
| chr8:119,638,540–119,639,410 | 34.5 kb | Distal (>10kb) Multiome | 275 | |
| chr8:119,672,030–119,673,835 | 142 bp | At TSS Multiome | 397 | |
| chr8:119,674,192–119,674,910 | 739 bp | At TSS | 16 | |
| chr8:119,677,512–119,678,310 | 4.1 kb | Proximal (<10kb) | 69 | |
| chr8:119,717,408–119,717,936 | 44.1 kb | Distal (>10kb) Multiome | 48 | |
| chr8:119,767,312–119,768,267 | 94.2 kb | Distal (>10kb) Multiome | 559 | |
| chr8:119,832,338–119,833,429 | 159.4 kb | Distal (>10kb) Multiome | 811 | |
| chr8:119,855,284–119,857,254 | 182.5 kb | Distal (>10kb) Multiome | 941 | |
| chr8:119,873,210–119,874,965 | 200.2 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the ENPP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.