Predicted to enable microtubule binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EML5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EML5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EML5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:88,551,095–88,552,499 | 241.3 kb | Distal (>10kb) Multiome | 512 | |
| chr14:88,554,467–88,555,337 | 238.1 kb | Distal (>10kb) Multiome | 594 | |
| chr14:88,562,461–88,563,844 | 229.8 kb | Distal (>10kb) Multiome | 904 | |
| chr14:88,791,992–88,793,502 | 19 bp | At TSS Multiome | 611 | |
| chr14:88,802,689–88,802,876 | 9.7 kb | Proximal (<10kb) | 9 | |
| chr14:88,824,077–88,825,117 | 31.6 kb | Distal (>10kb) Multiome | 798 | |
| chr14:88,978,957–88,979,452 | 186.1 kb | Distal (>10kb) Multiome | 182 | |
| chr14:89,026,793–89,028,061 | 234.5 kb | Distal (>10kb) Multiome | 495 | |
| chr14:89,040,230–89,041,239 | 247.7 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the EML5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.