ELOC

elongin C | SIII, TCEB1

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Member of: DE-1 Developmental clusters: GC5

Biological processes 28 terms

Cul2-RING ubiquitin ligase complex (GO:0031462)Cul2-RING ubiquitin ligase complex (GO:0031462)Cul5-RING ubiquitin ligase complex (GO:0031466)Cul5-RING ubiquitin ligase complex (GO:0031466)cytoplasm (GO:0005737)cytosol (GO:0005829)elongin complex (GO:0070449)elongin complex (GO:0070449)elongin complex (GO:0070449)negative regulation of DNA-templated DNA replication (GO:2000104)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein-macromolecule adaptor activity (GO:0030674)regulation of transcription by RNA polymerase II (GO:0006357)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)target-directed miRNA degradation (GO:0140958)transcription corepressor binding (GO:0001222)transcription initiation at RNA polymerase II promoter (GO:0006367)ubiquitin ligase complex (GO:0000151)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)

Expression (TPM)

TFs regulating ELOC 0 TFs

Transcription factors with Perturb-seq knockdown data for ELOC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ELOC

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:73,745,665–73,747,641	225.3 kb	Distal (>10kb) Multiome	863
chr8:73,877,680–73,879,555	93.4 kb	Distal (>10kb) Multiome	897
chr8:73,971,155–73,973,036	37 bp	At TSS Multiome	889
chr8:73,975,889–73,976,754	3.9 kb	Proximal (<10kb) Multiome	855
chr8:74,108,336–74,109,315	136.5 kb	Distal (>10kb) Multiome	221
chr8:74,115,763–74,116,601	143.9 kb	Distal (>10kb) Multiome	93
chr8:74,163,711–74,164,253	191.7 kb	Distal (>10kb) Multiome	63
chr8:74,320,238–74,322,101	348.3 kb	Distal (>10kb) Multiome HiCAR	590

Genome Browser

Genomic view of the ELOC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.