ELOB

elongin B | SIII, TCEB2

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Member of: DE-1 Developmental clusters: GC5

Biological processes 29 terms

Cul2-RING ubiquitin ligase complex (GO:0031462)Cul5-RING ubiquitin ligase complex (GO:0031466)Cul5-RING ubiquitin ligase complex (GO:0031466)VCB complex (GO:0030891)VCB complex (GO:0030891)cytoplasm (GO:0005737)cytosol (GO:0005829)elongin complex (GO:0070449)elongin complex (GO:0070449)elongin complex (GO:0070449)negative regulation of DNA-templated DNA replication (GO:2000104)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein-containing complex assembly (GO:0065003)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)target-directed miRNA degradation (GO:0140958)transcription corepressor binding (GO:0001222)transcription elongation by RNA polymerase II (GO:0006368)transcription elongation by RNA polymerase II (GO:0006368)transcription initiation at RNA polymerase II promoter (GO:0006367)ubiquitin ligase complex (GO:0000151)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)

Expression (TPM)

TFs regulating ELOB 0 TFs

Transcription factors with Perturb-seq knockdown data for ELOB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ELOB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:2,501,124–2,501,877	275.8 kb	Distal (>10kb) Multiome	471
chr16:2,513,006–2,514,809	263.5 kb	Distal (>10kb) Multiome	818
chr16:2,520,064–2,520,618	256.9 kb	Distal (>10kb) Multiome	624
chr16:2,531,456–2,533,080	245.2 kb	Distal (>10kb) Multiome	883
chr16:2,537,433–2,538,433	239.4 kb	Distal (>10kb) Multiome	498
chr16:2,603,176–2,603,939	173.9 kb	Distal (>10kb) Multiome	1066
chr16:2,673,059–2,673,910	103.8 kb	Distal (>10kb) Multiome	471
chr16:2,682,205–2,683,006	94.8 kb	Distal (>10kb) Multiome	1003
chr16:2,720,741–2,721,896	56.0 kb	Distal (>10kb) Multiome	758
chr16:2,751,637–2,753,398	24.8 kb	Distal (>10kb) Multiome	1074
chr16:2,776,766–2,778,256	47 bp	At TSS Multiome	828
chr16:2,867,958–2,868,665	91.1 kb	Distal (>10kb) Multiome	960
chr16:2,882,042–2,883,813	105.7 kb	Distal (>10kb) Multiome	838
chr16:2,904,002–2,906,321	127.0 kb	Distal (>10kb) Multiome	994
chr16:2,911,480–2,912,624	134.6 kb	Distal (>10kb) Multiome HiCAR	784
chr16:2,963,159–2,965,475	186.7 kb	Distal (>10kb) Multiome	628
chr16:2,968,641–2,970,561	191.9 kb	Distal (>10kb) Multiome	1039
chr16:2,979,651–2,981,140	203.2 kb	Distal (>10kb) Multiome	795
chr16:2,981,390–2,982,257	204.5 kb	Distal (>10kb) Multiome	460
chr16:3,003,612–3,004,589	226.8 kb	Distal (>10kb) Multiome	652
chr16:3,007,583–3,008,956	231.2 kb	Distal (>10kb) Multiome	514
chr16:3,009,722–3,010,376	232.8 kb	Distal (>10kb) Multiome	395
chr16:3,017,242–3,018,799	240.9 kb	Distal (>10kb) Multiome	451
chr16:3,019,969–3,022,268	243.0 kb	Distal (>10kb) Multiome	963
chr16:3,022,890–3,024,532	246.9 kb	Distal (>10kb) Multiome	933
chr16:3,027,854–3,029,038	251.1 kb	Distal (>10kb) Multiome	546
chr16:3,036,222–3,037,148	259.6 kb	Distal (>10kb) Multiome	256
chr16:3,045,413–3,047,408	268.9 kb	Distal (>10kb) Multiome	510
chr16:3,058,226–3,060,102	282.1 kb	Distal (>10kb) Multiome	769

Genome Browser

Genomic view of the ELOB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.