The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for ELMO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELMO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELMO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:46,117,897–46,118,755 | 288.3 kb | Distal (>10kb) Multiome | 376 | |
| chr20:46,174,457–46,175,011 | 231.9 kb | Distal (>10kb) Multiome | 277 | |
| chr20:46,268,041–46,268,560 | 138.3 kb | Distal (>10kb) Multiome | 82 | |
| chr20:46,307,134–46,307,979 | 99.3 kb | Distal (>10kb) Multiome | 455 | |
| chr20:46,308,245–46,308,857 | 98.0 kb | Distal (>10kb) Multiome | 287 | |
| chr20:46,363,898–46,364,657 | 42.3 kb | Distal (>10kb) Multiome | 983 | |
| chr20:46,405,903–46,407,320 | 68 bp | At TSS Multiome | 946 | |
| chr20:46,411,038–46,411,212 | 4.4 kb | Proximal (<10kb) | 331 | |
| chr20:46,459,001–46,459,476 | 52.7 kb | Distal (>10kb) Multiome | 157 | |
| chr20:46,513,244–46,513,752 | 107.0 kb | Distal (>10kb) Multiome | 458 | |
| chr20:46,562,567–46,563,148 | 156.2 kb | Distal (>10kb) Multiome | 483 | |
| chr20:46,583,359–46,584,278 | 177.2 kb | Distal (>10kb) Multiome | 196 | |
| chr20:46,648,981–46,649,761 | 242.7 kb | Distal (>10kb) Multiome | 275 | |
| chr20:46,651,152–46,651,711 | 244.8 kb | Distal (>10kb) Multiome | 558 | |
| chr20:46,688,904–46,689,939 | 283.0 kb | Distal (>10kb) Multiome | 940 |
Genomic view of the ELMO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.