Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for EIF5A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF5A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF5A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:170,418,375–170,421,188 | 488.3 kb | Distal (>10kb) Multiome HiCAR | 413 | |
| chr3:170,425,589–170,426,593 | 482.4 kb | Distal (>10kb) Multiome HiCAR | 432 | |
| chr3:170,685,663–170,686,879 | 222.6 kb | Distal (>10kb) Multiome | 9 | |
| chr3:170,697,673–170,698,830 | 210.4 kb | Distal (>10kb) Multiome | 176 | |
| chr3:170,817,407–170,818,229 | 90.8 kb | Distal (>10kb) Multiome | 68 | |
| chr3:170,907,922–170,909,058 | 25 bp | At TSS Multiome | 823 | |
| chr3:171,028,067–171,029,014 | 120.0 kb | Distal (>10kb) Multiome | 377 | |
| chr3:171,155,431–171,157,795 | 248.0 kb | Distal (>10kb) Multiome | 501 |
Genomic view of the EIF5A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.