EIF5A
eukaryotic translation initiation factor 5A | EIF-5A, EIF5A1, MGC104255, MGC99547

Enables U6 snRNA binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 Developmental clusters: GC3
Biological processes 28 terms
RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)U6 snRNA binding (GO:0017070)annulate lamellae (GO:0005642)cellular response to virus (GO:0098586)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)membrane (GO:0016020)nuclear pore (GO:0005643)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902255)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of translational elongation (GO:0045901)protein binding (GO:0005515)ribosome binding (GO:0043022)translation elongation factor activity (GO:0003746)translation elongation factor activity (GO:0003746)translation elongation factor activity (GO:0003746)translational elongation (GO:0006414)translational elongation (GO:0006414)translational elongation (GO:0006414)tumor necrosis factor-mediated signaling pathway (GO:0033209)
Expression (TPM)
EIF5A — as a Regulated Gene

TFs regulating EIF5A 0 TFs

Transcription factors with Perturb-seq knockdown data for EIF5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to EIF5A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,012,245–7,012,890 295.1 kb Distal (>10kb) Multiome 804
chr17:7,014,335–7,015,213 292.8 kb Distal (>10kb) Multiome 842
chr17:7,021,831–7,024,265 283.7 kb Distal (>10kb) Multiome 614
chr17:7,035,527–7,036,637 271.6 kb Distal (>10kb) Multiome 791
chr17:7,132,532–7,133,109 174.8 kb Distal (>10kb) Multiome 312
chr17:7,177,263–7,177,909 130.1 kb Distal (>10kb) Multiome 453
chr17:7,204,820–7,205,551 102.5 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 99.4 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 93.1 kb Distal (>10kb) Multiome 737
chr17:7,219,603–7,220,515 87.7 kb Distal (>10kb) Multiome 793
chr17:7,233,847–7,235,210 73.1 kb Distal (>10kb) Multiome 1020
chr17:7,237,531–7,238,757 69.6 kb Distal (>10kb) Multiome 502
chr17:7,238,867–7,240,155 67.9 kb Distal (>10kb) Multiome 783
chr17:7,241,494–7,243,462 64.5 kb Distal (>10kb) Multiome 1037
chr17:7,251,263–7,252,962 55.4 kb Distal (>10kb) Multiome 985
chr17:7,260,746–7,263,748 45.0 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 25.9 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 12.8 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 11.0 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 192 bp At TSS Multiome 896
chr17:7,314,722–7,315,725 7.7 kb Proximal (<10kb) Multiome 843
chr17:7,328,881–7,330,972 21.9 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 42.7 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 44.5 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 48.7 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 76.6 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 87.1 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 96.8 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 129.5 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 130.7 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 133.1 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 138.0 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 148.1 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 172.0 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 176.9 kb Distal (>10kb) Multiome 1156
chr17:7,548,693–7,549,285 241.4 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 254.4 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 266.3 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 271.9 kb Distal (>10kb) Multiome 844
chr17:7,583,063–7,584,547 276.2 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 282.6 kb Distal (>10kb) Multiome 319

Genome Browser

Genomic view of the EIF5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,002,245 – 7,600,534
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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