The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for EIF4G3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4G3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4G3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:20,661,099–20,662,130 | 515.3 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr1:20,696,319–20,697,384 | 480.0 kb | Distal (>10kb) Multiome HiCAR | 727 | |
| chr1:20,717,384–20,718,370 | 459.0 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr1:21,175,743–21,177,594 | 157 bp | At TSS Multiome | 807 | |
| chr1:21,289,691–21,290,756 | 113.2 kb | Distal (>10kb) Multiome | 389 | |
| chr1:21,344,857–21,346,026 | 168.8 kb | Distal (>10kb) Multiome | 850 | |
| chr1:21,436,521–21,437,523 | 260.2 kb | Distal (>10kb) Multiome | 100 | |
| chr1:21,439,762–21,440,452 | 263.3 kb | Distal (>10kb) Multiome | 454 |
Genomic view of the EIF4G3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.