Enables RNA 7-methylguanosine cap binding activity; mRNA cap binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of translational initiation; negative regulation of type I interferon-mediated signaling pathway; and rescue of stalled ribosome. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EIF4E2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4E2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4E2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:232,366,715–232,368,180 | 182.9 kb | Distal (>10kb) Multiome | 141 | |
| chr2:232,404,400–232,405,216 | 145.9 kb | Distal (>10kb) Multiome | 92 | |
| chr2:232,420,461–232,421,549 | 129.7 kb | Distal (>10kb) Multiome | 314 | |
| chr2:232,423,141–232,423,928 | 127.1 kb | Distal (>10kb) Multiome | 59 | |
| chr2:232,487,095–232,488,614 | 62.7 kb | Distal (>10kb) Multiome | 195 | |
| chr2:232,502,853–232,503,842 | 47.4 kb | Distal (>10kb) Multiome | 267 | |
| chr2:232,521,933–232,522,564 | 28.4 kb | Distal (>10kb) Multiome | 295 | |
| chr2:232,523,649–232,524,530 | 26.4 kb | Distal (>10kb) Multiome | 409 | |
| chr2:232,550,181–232,551,341 | 34 bp | At TSS Multiome | 1139 | |
| chr2:232,605,843–232,606,606 | 55.5 kb | Distal (>10kb) Multiome | 604 | |
| chr2:232,633,106–232,634,804 | 82.9 kb | Distal (>10kb) Multiome | 747 | |
| chr2:232,696,754–232,698,213 | 146.6 kb | Distal (>10kb) Multiome | 927 |
Genomic view of the EIF4E2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.