The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for EIF4E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:98,657,441–98,659,697 | 270.4 kb | Distal (>10kb) Multiome | 530 | |
| chr4:98,662,638–98,663,403 | 266.1 kb | Distal (>10kb) Multiome | 278 | |
| chr4:98,673,889–98,675,522 | 254.5 kb | Distal (>10kb) Multiome HiCAR | 226 | |
| chr4:98,747,334–98,748,149 | 181.4 kb | Distal (>10kb) Multiome | 231 | |
| chr4:98,800,757–98,802,020 | 127.7 kb | Distal (>10kb) Multiome | 287 | |
| chr4:98,927,921–98,930,006 | 144 bp | At TSS Multiome | 1003 | |
| chr4:98,994,750–98,996,989 | 66.5 kb | Distal (>10kb) Multiome | 958 | |
| chr4:99,088,011–99,089,765 | 159.7 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the EIF4E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.