Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EIF4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:52,714,144–52,714,803 | 291.8 kb | Distal (>10kb) Multiome | 145 | |
| chr12:52,879,361–52,880,433 | 126.4 kb | Distal (>10kb) Multiome HiCAR | 702 | |
| chr12:52,884,158–52,885,336 | 121.5 kb | Distal (>10kb) Multiome HiCAR | 610 | |
| chr12:52,903,331–52,905,680 | 102.6 kb | Distal (>10kb) Multiome | 985 | |
| chr12:52,906,476–52,907,649 | 99.0 kb | Distal (>10kb) Multiome | 424 | |
| chr12:52,945,414–52,946,146 | 60.5 kb | Distal (>10kb) Multiome | 514 | |
| chr12:52,948,516–52,950,156 | 57.3 kb | Distal (>10kb) Multiome | 923 | |
| chr12:53,004,143–53,004,532 | 1.7 kb | Proximal (<10kb) | 55 | |
| chr12:53,005,438–53,007,356 | 27 bp | At TSS Multiome | 995 | |
| chr12:53,046,385–53,049,295 | 41.1 kb | Distal (>10kb) Multiome HiCAR | 793 | |
| chr12:53,049,465–53,050,530 | 43.6 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr12:53,053,508–53,054,860 | 48.2 kb | Distal (>10kb) Multiome | 646 | |
| chr12:53,078,790–53,079,991 | 73.1 kb | Distal (>10kb) Multiome | 835 | |
| chr12:53,097,544–53,098,160 | 91.4 kb | Distal (>10kb) Multiome | 515 | |
| chr12:53,174,900–53,175,484 | 169.0 kb | Distal (>10kb) Multiome | 474 | |
| chr12:53,179,987–53,181,456 | 174.4 kb | Distal (>10kb) Multiome | 930 | |
| chr12:53,219,787–53,222,151 | 214.8 kb | Distal (>10kb) Multiome | 828 | |
| chr12:53,231,703–53,233,098 | 226.1 kb | Distal (>10kb) Multiome | 464 | |
| chr12:53,251,461–53,252,566 | 245.7 kb | Distal (>10kb) Multiome | 825 | |
| chr12:53,268,046–53,268,600 | 262.0 kb | Distal (>10kb) Multiome | 709 | |
| chr12:53,295,142–53,295,823 | 289.2 kb | Distal (>10kb) Multiome | 706 | |
| chr12:53,299,515–53,300,187 | 293.5 kb | Distal (>10kb) Multiome | 849 | |
| chr12:53,321,051–53,322,029 | 315.2 kb | Distal (>10kb) Multiome | 935 | |
| chr12:53,324,682–53,326,037 | 318.7 kb | Distal (>10kb) Multiome | 840 |
Genomic view of the EIF4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.