This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for EIF3M. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3M upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3M, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:32,333,136–32,334,160 | 250.2 kb | Distal (>10kb) Multiome | 216 | |
| chr11:32,334,700–32,335,307 | 248.8 kb | Distal (>10kb) Multiome HiCAR | 173 | |
| chr11:32,430,504–32,431,526 | 152.6 kb | Distal (>10kb) Multiome | 180 | |
| chr11:32,433,949–32,436,637 | 149.2 kb | Distal (>10kb) Multiome | 544 | |
| chr11:32,575,172–32,575,367 | 8.5 kb | Proximal (<10kb) | 18 | |
| chr11:32,583,226–32,584,622 | 64 bp | At TSS Multiome | 913 | |
| chr11:32,591,049–32,591,308 | 7.2 kb | Proximal (<10kb) | 17 | |
| chr11:32,829,540–32,830,458 | 246.1 kb | Distal (>10kb) Multiome | 566 |
Genomic view of the EIF3M locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.