Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EIF3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,559,893–37,560,965 | 289.1 kb | Distal (>10kb) Multiome | 589 | |
| chr22:37,569,013–37,570,549 | 279.9 kb | Distal (>10kb) Multiome | 695 | |
| chr22:37,608,044–37,609,455 | 240.6 kb | Distal (>10kb) Multiome | 920 | |
| chr22:37,639,157–37,639,951 | 209.8 kb | Distal (>10kb) Multiome | 427 | |
| chr22:37,658,172–37,659,508 | 190.8 kb | Distal (>10kb) Multiome | 722 | |
| chr22:37,674,916–37,675,641 | 174.0 kb | Distal (>10kb) Multiome | 607 | |
| chr22:37,676,590–37,677,674 | 172.2 kb | Distal (>10kb) Multiome | 655 | |
| chr22:37,686,104–37,686,784 | 163.0 kb | Distal (>10kb) Multiome | 866 | |
| chr22:37,696,496–37,697,685 | 152.5 kb | Distal (>10kb) Multiome | 428 | |
| chr22:37,745,641–37,746,995 | 103.3 kb | Distal (>10kb) Multiome | 627 | |
| chr22:37,802,124–37,802,989 | 47.0 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 44.2 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 41.6 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 31.5 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 24.4 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 5.0 kb | Proximal (<10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 27 bp | At TSS Multiome | 753 | |
| chr22:37,905,849–37,906,846 | 56.8 kb | Distal (>10kb) Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 84.7 kb | Distal (>10kb) Multiome | 679 | |
| chr22:37,953,153–37,954,120 | 104.2 kb | Distal (>10kb) Multiome | 617 | |
| chr22:37,983,021–37,985,110 | 135.0 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 203.1 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 207.9 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 231.7 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 248.5 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the EIF3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.