The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for EIF2B3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2B3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2B3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:44,720,791–44,722,329 | 264.9 kb | Distal (>10kb) Multiome | 1059 | |
| chr1:44,730,465–44,731,848 | 255.5 kb | Distal (>10kb) Multiome | 1164 | |
| chr1:44,739,368–44,740,265 | 246.8 kb | Distal (>10kb) Multiome | 828 | |
| chr1:44,775,008–44,776,007 | 211.1 kb | Distal (>10kb) Multiome | 1041 | |
| chr1:44,783,907–44,784,940 | 202.2 kb | Distal (>10kb) Multiome | 497 | |
| chr1:44,786,163–44,786,815 | 200.2 kb | Distal (>10kb) Multiome | 616 | |
| chr1:44,799,477–44,801,039 | 186.5 kb | Distal (>10kb) Multiome HiCAR | 1017 | |
| chr1:44,807,115–44,808,920 | 178.0 kb | Distal (>10kb) Multiome | 987 | |
| chr1:44,812,965–44,814,105 | 172.8 kb | Distal (>10kb) Multiome | 349 | |
| chr1:44,818,937–44,820,693 | 166.7 kb | Distal (>10kb) Multiome | 1101 | |
| chr1:44,842,822–44,843,695 | 143.3 kb | Distal (>10kb) Multiome | 539 | |
| chr1:44,986,311–44,986,894 | 57 bp | At TSS Multiome | 979 | |
| chr1:45,010,856–45,013,180 | 25.6 kb | Distal (>10kb) Multiome | 909 | |
| chr1:45,205,664–45,207,097 | 219.9 kb | Distal (>10kb) Multiome | 691 | |
| chr1:45,216,712–45,217,234 | 230.4 kb | Distal (>10kb) Multiome | 42 | |
| chr1:45,303,203–45,304,881 | 317.2 kb | Distal (>10kb) Multiome HiCAR | 1034 |
Genomic view of the EIF2B3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.