The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Transcription factors with Perturb-seq knockdown data for EIF2AK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2AK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2AK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:36,965,735–36,967,324 | 190.4 kb | Distal (>10kb) Multiome | 1026 | |
| chr2:37,083,780–37,086,187 | 71.2 kb | Distal (>10kb) Multiome | 938 | |
| chr2:37,156,055–37,157,536 | 38 bp | At TSS Multiome | 702 | |
| chr2:37,205,153–37,205,870 | 48.4 kb | Distal (>10kb) Multiome | 157 | |
| chr2:37,231,272–37,232,043 | 74.6 kb | Distal (>10kb) Multiome | 891 | |
| chr2:37,305,706–37,306,783 | 149.1 kb | Distal (>10kb) Multiome | 129 | |
| chr2:37,323,791–37,325,583 | 167.8 kb | Distal (>10kb) Multiome | 835 | |
| chr2:37,443,019–37,443,805 | 286.4 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the EIF2AK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.