This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EIF1AX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF1AX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF1AX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:19,887,617–19,888,819 | 253.3 kb | Distal (>10kb) Multiome | 556 | |
| chrX:19,990,480–19,991,602 | 150.7 kb | Distal (>10kb) Multiome | 509 | |
| chrX:20,141,297–20,142,342 | 99 bp | At TSS Multiome | 557 | |
| chrX:20,266,335–20,268,799 | 125.2 kb | Distal (>10kb) Multiome | 680 | |
| chrX:20,322,527–20,323,563 | 181.3 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the EIF1AX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.