Predicted to enable RNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EIF1AD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF1AD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF1AD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,711,437–65,712,942 | 289.9 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 281.5 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 222.1 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 213.8 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 183.9 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 168.4 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 145.1 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 141.6 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 128.5 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 113.6 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 111.5 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 101.6 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 82.9 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 40.5 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 229 bp | At TSS Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 5.3 kb | Proximal (<10kb) Multiome | 100 | |
| chr11:66,010,080–66,010,400 | 7.9 kb | Proximal (<10kb) | 13 | |
| chr11:66,022,341–66,022,903 | 20.4 kb | Distal (>10kb) Multiome | 466 | |
| chr11:66,045,170–66,045,637 | 43.2 kb | Distal (>10kb) Multiome | 394 | |
| chr11:66,048,912–66,049,460 | 47.0 kb | Distal (>10kb) Multiome | 83 | |
| chr11:66,051,716–66,052,760 | 50.0 kb | Distal (>10kb) Multiome | 901 | |
| chr11:66,069,690–66,071,102 | 68.0 kb | Distal (>10kb) Multiome | 622 | |
| chr11:66,256,991–66,258,893 | 255.8 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 265.4 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 275.9 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 280.4 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 287.2 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the EIF1AD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.