The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EFNB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFNB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFNB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:68,686,156–68,686,853 | 142.6 kb | Distal (>10kb) Multiome | 235 | |
| chrX:68,693,384–68,694,277 | 135.4 kb | Distal (>10kb) Multiome | 303 | |
| chrX:68,822,652–68,822,951 | 6.1 kb | Proximal (<10kb) | 107 | |
| chrX:68,827,840–68,829,986 | 46 bp | At TSS Multiome | 560 | |
| chrX:69,107,160–69,107,846 | 278.5 kb | Distal (>10kb) Multiome | 219 | |
| chrX:69,222,159–69,222,593 | 393.4 kb | Distal (>10kb) Multiome HiCAR | 178 | |
| chrX:69,277,773–69,278,348 | 449.1 kb | Distal (>10kb) Multiome HiCAR | 52 |
Genomic view of the EFNB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.