This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for EFCAB6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:43,226,308–43,226,848 | 585.6 kb | Distal (>10kb) Multiome HiCAR | 56 | |
| chr22:43,812,012–43,812,763 | 163 bp | At TSS Multiome | 493 | |
| chr22:43,861,938–43,862,881 | 50.3 kb | Distal (>10kb) Multiome | 263 | |
| chr22:43,891,548–43,892,393 | 79.8 kb | Distal (>10kb) Multiome | 185 | |
| chr22:43,923,130–43,924,772 | 111.6 kb | Distal (>10kb) Multiome | 741 | |
| chr22:43,925,117–43,926,046 | 113.4 kb | Distal (>10kb) Multiome | 441 | |
| chr22:43,955,027–43,955,843 | 143.3 kb | Distal (>10kb) Multiome | 809 | |
| chr22:44,023,900–44,024,505 | 212.1 kb | Distal (>10kb) Multiome | 355 | |
| chr22:44,046,421–44,047,108 | 234.7 kb | Distal (>10kb) Multiome | 200 |
Genomic view of the EFCAB6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.