Predicted to enable calcium ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFCAB14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:46,442,171–46,443,351 | 276.4 kb | Distal (>10kb) Multiome | 649 | |
| chr1:46,448,113–46,448,679 | 270.6 kb | Distal (>10kb) Multiome | 143 | |
| chr1:46,466,221–46,467,348 | 252.4 kb | Distal (>10kb) Multiome | 398 | |
| chr1:46,489,045–46,490,312 | 229.4 kb | Distal (>10kb) Multiome | 381 | |
| chr1:46,516,974–46,517,563 | 201.9 kb | Distal (>10kb) Multiome | 328 | |
| chr1:46,525,135–46,525,776 | 193.7 kb | Distal (>10kb) Multiome | 169 | |
| chr1:46,526,636–46,527,311 | 192.1 kb | Distal (>10kb) Multiome | 225 | |
| chr1:46,532,918–46,533,689 | 185.9 kb | Distal (>10kb) Multiome | 254 | |
| chr1:46,603,644–46,604,906 | 114.9 kb | Distal (>10kb) Multiome | 784 | |
| chr1:46,616,228–46,617,226 | 102.4 kb | Distal (>10kb) Multiome | 517 | |
| chr1:46,667,821–46,668,764 | 50.7 kb | Distal (>10kb) Multiome | 668 | |
| chr1:46,689,209–46,690,044 | 29.6 kb | Distal (>10kb) Multiome | 143 | |
| chr1:46,718,615–46,719,657 | 107 bp | At TSS Multiome | 860 | |
| chr1:46,725,101–46,725,534 | 6.0 kb | Proximal (<10kb) | 288 | |
| chr1:46,788,642–46,789,579 | 69.9 kb | Distal (>10kb) Multiome | 28 |
Genomic view of the EFCAB14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.