Predicted to be involved in positive regulation of osteoclast differentiation. Predicted to be located in cytoplasm; membrane raft; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EEIG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEIG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEIG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,699,155–127,699,632 | 281.5 kb | Distal (>10kb) Multiome | 440 | |
| chr9:127,715,013–127,716,345 | 265.2 kb | Distal (>10kb) Multiome | 735 | |
| chr9:127,734,444–127,735,606 | 245.7 kb | Distal (>10kb) Multiome | 836 | |
| chr9:127,741,739–127,743,092 | 238.2 kb | Distal (>10kb) Multiome | 367 | |
| chr9:127,754,123–127,755,506 | 225.6 kb | Distal (>10kb) Multiome | 279 | |
| chr9:127,770,807–127,771,925 | 209.5 kb | Distal (>10kb) Multiome | 550 | |
| chr9:127,784,682–127,787,009 | 194.4 kb | Distal (>10kb) Multiome | 858 | |
| chr9:127,802,385–127,803,632 | 178.1 kb | Distal (>10kb) Multiome | 867 | |
| chr9:127,809,338–127,810,272 | 171.1 kb | Distal (>10kb) Multiome | 276 | |
| chr9:127,825,222–127,826,046 | 155.4 kb | Distal (>10kb) Multiome | 451 | |
| chr9:127,828,234–127,829,024 | 152.4 kb | Distal (>10kb) Multiome | 521 | |
| chr9:127,877,282–127,878,202 | 103.2 kb | Distal (>10kb) Multiome | 531 | |
| chr9:127,897,316–127,897,796 | 83.5 kb | Distal (>10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 81.4 kb | Distal (>10kb) Multiome | 630 | |
| chr9:127,916,386–127,917,505 | 63.9 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 53.5 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 50.2 kb | Distal (>10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 43.1 kb | Distal (>10kb) Multiome | 674 | |
| chr9:127,955,445–127,955,915 | 25.4 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,979,345–127,980,012 | 976 bp | At TSS | 442 | |
| chr9:127,980,172–127,981,966 | 127 bp | At TSS Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 52.9 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 54.4 kb | Distal (>10kb) Multiome | 480 | |
| chr9:128,066,577–128,068,774 | 86.4 kb | Distal (>10kb) Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 117.4 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 136.9 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 147.3 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 179.1 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 210.7 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 223.4 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 237.9 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 269.6 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 295.1 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the EEIG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.