This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for EEF1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,334,216–143,335,267 | 262.5 kb | Distal (>10kb) Multiome | 688 | |
| chr8:143,368,147–143,369,893 | 228.7 kb | Distal (>10kb) Multiome | 698 | |
| chr8:143,407,212–143,408,612 | 189.3 kb | Distal (>10kb) Multiome | 447 | |
| chr8:143,428,968–143,431,754 | 166.5 kb | Distal (>10kb) Multiome | 743 | |
| chr8:143,540,714–143,542,061 | 55.9 kb | Distal (>10kb) Multiome | 849 | |
| chr8:143,553,122–143,554,177 | 43.7 kb | Distal (>10kb) Multiome | 775 | |
| chr8:143,558,225–143,558,936 | 38.9 kb | Distal (>10kb) Multiome | 600 | |
| chr8:143,567,166–143,570,227 | 28.3 kb | Distal (>10kb) Multiome | 485 | |
| chr8:143,571,367–143,572,283 | 25.6 kb | Distal (>10kb) Multiome | 443 | |
| chr8:143,577,641–143,578,799 | 19.0 kb | Distal (>10kb) Multiome | 470 | |
| chr8:143,596,214–143,596,600 | 510 bp | At TSS | 314 | |
| chr8:143,596,744–143,599,643 | 191 bp | At TSS Multiome | 973 | |
| chr8:143,608,979–143,610,357 | 12.3 kb | Distal (>10kb) Multiome | 735 | |
| chr8:143,617,068–143,618,380 | 20.2 kb | Distal (>10kb) Multiome | 823 | |
| chr8:143,635,715–143,636,601 | 38.6 kb | Distal (>10kb) Multiome | 786 | |
| chr8:143,684,308–143,684,747 | 87.0 kb | Distal (>10kb) Multiome | 686 | |
| chr8:143,716,075–143,716,913 | 118.9 kb | Distal (>10kb) Multiome | 311 | |
| chr8:143,733,345–143,734,440 | 136.4 kb | Distal (>10kb) Multiome | 663 | |
| chr8:143,740,039–143,740,754 | 143.1 kb | Distal (>10kb) Multiome | 308 | |
| chr8:143,771,202–143,772,221 | 174.4 kb | Distal (>10kb) Multiome | 405 | |
| chr8:143,814,945–143,816,493 | 218.4 kb | Distal (>10kb) Multiome | 893 | |
| chr8:143,828,724–143,829,946 | 232.0 kb | Distal (>10kb) Multiome | 933 | |
| chr8:143,840,284–143,841,979 | 243.7 kb | Distal (>10kb) Multiome | 551 | |
| chr8:143,877,814–143,879,346 | 281.1 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the EEF1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.