This gene encodes a member of the lysine-specific methyltransferase (KMT) family. The encoded enzyme catalyzes the methylation of lysine-36 of the eukaryotic translation elongation factor 1 alpha. Methylation by this enzyme may affect endoplasmic reticulum-related processes. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for EEF1AKMT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF1AKMT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF1AKMT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:183,884,110–183,885,311 | 364.7 kb | Distal (>10kb) Multiome HiCAR | 972 | |
| chr3:184,017,103–184,018,456 | 231.8 kb | Distal (>10kb) Multiome | 878 | |
| chr3:184,134,086–184,134,568 | 115.5 kb | Distal (>10kb) Multiome | 732 | |
| chr3:184,134,801–184,135,887 | 114.2 kb | Distal (>10kb) Multiome | 941 | |
| chr3:184,154,967–184,155,880 | 94.3 kb | Distal (>10kb) Multiome HiCAR | 580 | |
| chr3:184,174,432–184,175,524 | 74.9 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr3:184,176,129–184,177,706 | 73.0 kb | Distal (>10kb) Multiome HiCAR | 480 | |
| chr3:184,185,411–184,187,065 | 63.7 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr3:184,229,229–184,229,859 | 20.2 kb | Distal (>10kb) Multiome | 409 | |
| chr3:184,241,140–184,242,189 | 7.9 kb | Proximal (<10kb) Multiome | 700 | |
| chr3:184,248,652–184,250,567 | 58 bp | At TSS Multiome | 1061 | |
| chr3:184,255,398–184,255,628 | 5.7 kb | Proximal (<10kb) | 22 | |
| chr3:184,259,723–184,260,497 | 10.3 kb | Distal (>10kb) Multiome | 318 | |
| chr3:184,260,815–184,262,571 | 12.0 kb | Distal (>10kb) Multiome | 511 | |
| chr3:184,298,591–184,299,718 | 49.4 kb | Distal (>10kb) Multiome HiCAR | 768 | |
| chr3:184,314,169–184,315,514 | 64.9 kb | Distal (>10kb) Multiome | 761 | |
| chr3:184,335,265–184,337,276 | 86.3 kb | Distal (>10kb) Multiome | 796 | |
| chr3:184,338,471–184,338,964 | 89.1 kb | Distal (>10kb) Multiome | 203 | |
| chr3:184,361,172–184,363,709 | 112.0 kb | Distal (>10kb) Multiome | 1034 | |
| chr3:184,379,849–184,380,935 | 130.5 kb | Distal (>10kb) Multiome | 242 | |
| chr3:184,513,458–184,514,228 | 264.2 kb | Distal (>10kb) Multiome | 391 | |
| chr3:184,525,317–184,526,423 | 276.3 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the EEF1AKMT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.