EEF1A2

eukaryotic translation elongation factor 1 alpha 2 | EEF1AL, HS1, STN, STNL

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

Developmental clusters: GC2

Biological processes 25 terms

GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of lysosomal membrane (GO:0098574)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)eukaryotic translation elongation factor 1 complex (GO:0005853)nucleus (GO:0005634)positive regulation of lipid kinase activity (GO:0090218)protein binding (GO:0005515)protein kinase binding (GO:0019901)regulation of chaperone-mediated autophagy (GO:1904714)synapse (GO:0045202)translation (GO:0006412)translation elongation factor activity (GO:0003746)translation elongation factor activity (GO:0003746)translation elongation factor activity (GO:0003746)translation factor activity, RNA binding (GO:0008135)translational elongation (GO:0006414)translational elongation (GO:0006414)translational elongation (GO:0006414)translational elongation (GO:0006414)

Expression (TPM)

TFs regulating EEF1A2 0 TFs

Transcription factors with Perturb-seq knockdown data for EEF1A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF1A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to EEF1A2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF1A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:63,215,706–63,216,790	282.8 kb	Distal (>10kb) Multiome	965
chr20:63,272,274–63,273,137	226.3 kb	Distal (>10kb) Multiome	736
chr20:63,409,631–63,410,124	89.2 kb	Distal (>10kb) Multiome	60
chr20:63,471,533–63,472,788	26.4 kb	Distal (>10kb) Multiome	219
chr20:63,488,166–63,488,632	10.6 kb	Distal (>10kb) Multiome	127
chr20:63,496,187–63,496,363	2.7 kb	Proximal (<10kb)	355
chr20:63,498,850–63,499,391	186 bp	At TSS Multiome	232
chr20:63,519,657–63,521,677	21.5 kb	Distal (>10kb) Multiome	712
chr20:63,537,759–63,538,455	39.0 kb	Distal (>10kb) Multiome	823
chr20:63,552,551–63,554,733	54.5 kb	Distal (>10kb) Multiome	544
chr20:63,573,969–63,574,596	75.2 kb	Distal (>10kb) Multiome	551
chr20:63,626,480–63,627,647	127.9 kb	Distal (>10kb) Multiome	982
chr20:63,641,266–63,642,913	143.0 kb	Distal (>10kb) Multiome	691
chr20:63,652,233–63,654,166	154.5 kb	Distal (>10kb) Multiome	1011
chr20:63,657,813–63,658,939	159.4 kb	Distal (>10kb) Multiome	1055
chr20:63,696,254–63,697,070	197.5 kb	Distal (>10kb) Multiome	458
chr20:63,707,489–63,708,488	208.9 kb	Distal (>10kb) Multiome	1008
chr20:63,737,573–63,741,470	240.6 kb	Distal (>10kb) Multiome	1098
chr20:63,775,216–63,775,997	276.4 kb	Distal (>10kb) Multiome	257

Genome Browser

Genomic view of the EEF1A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.