In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for EDEM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EDEM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EDEM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,872,384–34,873,259 | 274.5 kb | Distal (>10kb) Multiome | 817 | |
| chr20:34,874,110–34,874,535 | 273.0 kb | Distal (>10kb) Multiome | 357 | |
| chr20:34,875,878–34,877,081 | 270.9 kb | Distal (>10kb) Multiome | 852 | |
| chr20:34,955,039–34,956,224 | 191.5 kb | Distal (>10kb) Multiome | 1031 | |
| chr20:34,960,537–34,961,054 | 186.5 kb | Distal (>10kb) Multiome | 275 | |
| chr20:34,979,568–34,980,289 | 167.4 kb | Distal (>10kb) Multiome | 149 | |
| chr20:35,092,320–35,093,398 | 54.5 kb | Distal (>10kb) Multiome | 1139 | |
| chr20:35,146,563–35,147,734 | 77 bp | At TSS Multiome | 992 | |
| chr20:35,171,731–35,172,358 | 24.7 kb | Distal (>10kb) Multiome | 383 | |
| chr20:35,174,680–35,175,277 | 27.6 kb | Distal (>10kb) Multiome | 635 | |
| chr20:35,262,839–35,263,582 | 116.0 kb | Distal (>10kb) Multiome HiCAR | 336 | |
| chr20:35,269,197–35,269,766 | 122.1 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr20:35,277,415–35,278,519 | 130.7 kb | Distal (>10kb) Multiome HiCAR | 575 | |
| chr20:35,284,235–35,285,360 | 137.4 kb | Distal (>10kb) Multiome | 950 | |
| chr20:35,303,859–35,304,479 | 156.7 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the EDEM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.