This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for EDC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EDC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EDC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:74,433,053–74,434,500 | 262.1 kb | Distal (>10kb) Multiome | 695 | |
| chr15:74,460,798–74,461,761 | 234.8 kb | Distal (>10kb) Multiome | 925 | |
| chr15:74,531,382–74,531,884 | 164.4 kb | Distal (>10kb) Multiome | 217 | |
| chr15:74,540,389–74,542,119 | 154.9 kb | Distal (>10kb) Multiome | 838 | |
| chr15:74,598,102–74,598,966 | 97.5 kb | Distal (>10kb) Multiome | 689 | |
| chr15:74,614,343–74,616,348 | 80.2 kb | Distal (>10kb) Multiome | 1019 | |
| chr15:74,695,758–74,696,387 | 52 bp | At TSS Multiome | 775 | |
| chr15:74,720,336–74,720,840 | 24.6 kb | Distal (>10kb) Multiome | 16 | |
| chr15:74,725,773–74,726,537 | 30.2 kb | Distal (>10kb) Multiome | 607 | |
| chr15:74,759,107–74,760,837 | 64.4 kb | Distal (>10kb) Multiome | 637 | |
| chr15:74,761,837–74,762,260 | 66.1 kb | Distal (>10kb) Multiome | 34 | |
| chr15:74,770,975–74,771,578 | 75.3 kb | Distal (>10kb) Multiome | 485 | |
| chr15:74,781,439–74,783,648 | 86.1 kb | Distal (>10kb) Multiome | 679 | |
| chr15:74,842,412–74,843,723 | 147.0 kb | Distal (>10kb) Multiome | 879 | |
| chr15:74,872,771–74,874,092 | 177.2 kb | Distal (>10kb) Multiome | 758 | |
| chr15:74,889,894–74,890,629 | 194.1 kb | Distal (>10kb) Multiome | 816 | |
| chr15:74,905,926–74,907,376 | 210.8 kb | Distal (>10kb) Multiome | 743 | |
| chr15:74,937,494–74,938,710 | 242.1 kb | Distal (>10kb) Multiome | 998 | |
| chr15:74,950,147–74,950,911 | 254.6 kb | Distal (>10kb) Multiome | 326 | |
| chr15:74,954,536–74,955,001 | 258.7 kb | Distal (>10kb) Multiome | 348 | |
| chr15:74,955,873–74,957,720 | 260.8 kb | Distal (>10kb) Multiome | 776 | |
| chr15:74,958,363–74,959,586 | 262.6 kb | Distal (>10kb) Multiome | 282 | |
| chr15:74,995,116–74,996,280 | 299.5 kb | Distal (>10kb) Multiome | 825 |
Genomic view of the EDC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.