This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for EAPP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EAPP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EAPP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,331,736–34,332,458 | 207.6 kb | Distal (>10kb) Multiome | 698 | |
| chr14:34,461,634–34,463,144 | 77.4 kb | Distal (>10kb) Multiome | 931 | |
| chr14:34,629,461–34,630,514 | 90.4 kb | Distal (>10kb) Multiome | 907 | |
| chr14:34,693,166–34,693,989 | 153.6 kb | Distal (>10kb) Multiome | 463 | |
| chr14:34,713,982–34,715,044 | 174.9 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the EAPP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.