Enables BBSome binding activity and molecular adaptor activity. Involved in cilium organization; heart development; and protein-containing complex localization to centriolar satellite. Located in cytosol; microtubule organizing center; and nucleoplasm. Implicated in mitral valve prolapse and spermatogenic failure 47. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DZIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DZIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DZIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:95,359,817–95,361,148 | 284.2 kb | Distal (>10kb) Multiome | 216 | |
| chr13:95,403,573–95,404,765 | 240.4 kb | Distal (>10kb) Multiome | 412 | |
| chr13:95,552,034–95,553,905 | 92.0 kb | Distal (>10kb) Multiome | 283 | |
| chr13:95,637,285–95,637,549 | 7.1 kb | Proximal (<10kb) | 9 | |
| chr13:95,641,248–95,642,446 | 2.7 kb | Proximal (<10kb) Multiome | 290 | |
| chr13:95,643,560–95,645,129 | 4 bp | At TSS Multiome | 600 | |
| chr13:95,676,126–95,678,015 | 32.4 kb | Distal (>10kb) Multiome HiCAR | 948 |
Genomic view of the DZIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.