This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for DYRK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYRK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYRK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:4,307,615–4,308,315 | 297.0 kb | Distal (>10kb) Multiome | 391 | |
| chr12:4,320,509–4,321,663 | 283.9 kb | Distal (>10kb) Multiome | 743 | |
| chr12:4,538,204–4,539,165 | 66.2 kb | Distal (>10kb) Multiome | 740 | |
| chr12:4,562,041–4,562,555 | 42.7 kb | Distal (>10kb) Multiome | 486 | |
| chr12:4,604,713–4,605,166 | 51 bp | At TSS Multiome | 580 | |
| chr12:4,648,527–4,649,423 | 44.1 kb | Distal (>10kb) Multiome | 645 | |
| chr12:4,720,395–4,720,946 | 115.8 kb | Distal (>10kb) Multiome | 69 | |
| chr12:4,809,137–4,810,290 | 204.4 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the DYRK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.