This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for DYNC2I2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNC2I2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNC2I2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,364,858–128,365,437 | 291.6 kb | Distal (>10kb) Multiome | 442 | |
| chr9:128,420,259–128,421,260 | 235.9 kb | Distal (>10kb) Multiome | 701 | |
| chr9:128,455,721–128,456,522 | 200.6 kb | Distal (>10kb) Multiome | 684 | |
| chr9:128,504,482–128,505,188 | 152.0 kb | Distal (>10kb) Multiome | 766 | |
| chr9:128,552,006–128,553,125 | 104.2 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,656,436–128,657,126 | 156 bp | At TSS Multiome | 1009 | |
| chr9:128,683,393–128,684,010 | 27.0 kb | Distal (>10kb) Multiome | 296 | |
| chr9:128,684,170–128,684,813 | 28.1 kb | Distal (>10kb) Multiome | 574 | |
| chr9:128,688,449–128,689,713 | 32.4 kb | Distal (>10kb) Multiome | 805 | |
| chr9:128,702,246–128,702,946 | 45.9 kb | Distal (>10kb) Multiome | 720 | |
| chr9:128,723,691–128,725,229 | 67.6 kb | Distal (>10kb) Multiome | 821 | |
| chr9:128,771,658–128,772,301 | 115.3 kb | Distal (>10kb) Multiome | 940 | |
| chr9:128,786,928–128,787,516 | 130.5 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 161.8 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 173.2 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 225.4 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | 265.6 kb | Distal (>10kb) Multiome | 378 | |
| chr9:128,947,329–128,947,815 | 291.0 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the DYNC2I2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.