This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for DYNC2I1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNC2I1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNC2I1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:158,587,414–158,588,855 | 291.9 kb | Distal (>10kb) Multiome | 384 | |
| chr7:158,704,389–158,705,515 | 174.8 kb | Distal (>10kb) Multiome | 894 | |
| chr7:158,828,327–158,830,454 | 51.3 kb | Distal (>10kb) Multiome | 1104 | |
| chr7:158,855,976–158,857,103 | 23.2 kb | Distal (>10kb) Multiome | 944 | |
| chr7:158,858,585–158,859,204 | 2.0 kb | Proximal (<10kb) | 165 | |
| chr7:158,863,230–158,864,395 | 15.8 kb | Distal (>10kb) Multiome | 534 | |
| chr7:158,976,471–158,977,488 | 97.4 kb | Distal (>10kb) Multiome | 458 | |
| chr7:159,030,257–159,031,567 | 151.0 kb | Distal (>10kb) Multiome | 560 | |
| chr7:159,141,671–159,142,509 | 262.3 kb | Distal (>10kb) Multiome | 169 | |
| chr7:159,142,805–159,143,658 | 263.5 kb | Distal (>10kb) Multiome | 119 | |
| chr7:159,144,286–159,145,801 | 265.3 kb | Distal (>10kb) Multiome | 255 |
Genomic view of the DYNC2I1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.