Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DYNC1I1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNC1I1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNC1I1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:95,549,589–95,550,472 | 222.6 kb | Distal (>10kb) Multiome | 407 | |
| chr7:95,595,916–95,597,166 | 176.0 kb | Distal (>10kb) Multiome | 538 | |
| chr7:95,772,187–95,773,636 | 14 bp | At TSS Multiome | 600 | |
| chr7:95,840,747–95,842,872 | 69.3 kb | Distal (>10kb) Multiome | 273 | |
| chr7:96,017,820–96,018,353 | 245.4 kb | Distal (>10kb) Multiome | 229 | |
| chr7:97,016,407–97,017,582 | 1244.2 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr7:97,023,662–97,025,361 | 1252.0 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr7:97,731,618–97,734,138 | 1961.0 kb | Distal (>10kb) Multiome HiCAR | 383 |
Genomic view of the DYNC1I1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.