Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for DUSP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:221,510,825–221,512,374 | 230.1 kb | Distal (>10kb) Multiome HiCAR | 216 | |
| chr1:221,611,822–221,612,802 | 129.7 kb | Distal (>10kb) Multiome | 504 | |
| chr1:221,741,206–221,744,237 | 175 bp | At TSS Multiome | 1085 | |
| chr1:221,964,631–221,965,405 | 222.9 kb | Distal (>10kb) Multiome HiCAR | 94 | |
| chr1:221,965,763–221,966,471 | 224.1 kb | Distal (>10kb) Multiome HiCAR | 27 | |
| chr1:222,028,164–222,028,641 | 286.3 kb | Distal (>10kb) Multiome | 97 | |
| chr1:222,031,101–222,031,767 | 289.4 kb | Distal (>10kb) Multiome | 98 |
Genomic view of the DUSP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.