Predicted to act upstream of or within several processes, including generation of neurons; negative regulation of macromolecule biosynthetic process; and protein stabilization. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DUBR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUBR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUBR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:107,233,444–107,233,620 | 7.1 kb | Proximal (<10kb) | 3 | |
| chr3:107,235,924–107,236,167 | 4.5 kb | Proximal (<10kb) | 231 | |
| chr3:107,237,025–107,237,235 | 3.4 kb | Proximal (<10kb) | 74 | |
| chr3:107,240,198–107,241,589 | 24 bp | At TSS Multiome | 500 | |
| chr3:107,284,662–107,285,977 | 44.7 kb | Distal (>10kb) Multiome | 210 | |
| chr3:107,429,360–107,430,595 | 189.3 kb | Distal (>10kb) Multiome HiCAR | 428 | |
| chr3:107,430,965–107,432,148 | 191.1 kb | Distal (>10kb) Multiome | 577 | |
| chr3:107,522,248–107,524,359 | 282.2 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the DUBR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.