Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including exocytic vesicle; growth cone; and lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in cytosol and synapse. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for DPYSL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPYSL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPYSL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:147,234,227–147,235,490 | 218.7 kb | Distal (>10kb) Multiome | 281 | |
| chr5:147,384,143–147,385,012 | 69.1 kb | Distal (>10kb) Multiome | 122 | |
| chr5:147,393,976–147,394,632 | 59.3 kb | Distal (>10kb) Multiome HiCAR | 84 | |
| chr5:147,451,234–147,451,397 | 2.3 kb | Proximal (<10kb) | 42 | |
| chr5:147,452,160–147,452,760 | 1.4 kb | Proximal (<10kb) Multiome HiCAR | 144 | |
| chr5:147,453,007–147,454,909 | 323 bp | At TSS Multiome | 558 | |
| chr5:147,455,429–147,455,644 | 1.7 kb | Proximal (<10kb) | 64 | |
| chr5:147,460,461–147,460,685 | 6.8 kb | Proximal (<10kb) | 17 | |
| chr5:147,508,911–147,510,481 | 56.3 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr5:147,567,516–147,569,131 | 114.5 kb | Distal (>10kb) Multiome HiCAR | 324 | |
| chr5:147,626,194–147,627,455 | 172.8 kb | Distal (>10kb) Multiome | 106 | |
| chr5:147,782,086–147,783,019 | 329.1 kb | Distal (>10kb) Multiome | 348 |
Genomic view of the DPYSL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.