This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for DPYSL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPYSL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPYSL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:26,290,938–26,292,152 | 286.4 kb | Distal (>10kb) Multiome | 690 | |
| chr8:26,382,644–26,384,037 | 194.6 kb | Distal (>10kb) Multiome | 915 | |
| chr8:26,448,172–26,450,526 | 128.4 kb | Distal (>10kb) Multiome | 708 | |
| chr8:26,513,536–26,515,319 | 62.7 kb | Distal (>10kb) Multiome | 359 | |
| chr8:26,571,297–26,571,701 | 6.1 kb | Proximal (<10kb) | 363 | |
| chr8:26,576,275–26,578,173 | 128 bp | At TSS Multiome | 854 | |
| chr8:26,578,278–26,579,326 | 436 bp | At TSS | 385 | |
| chr8:26,641,298–26,642,123 | 64.0 kb | Distal (>10kb) Multiome HiCAR | 636 | |
| chr8:26,661,625–26,662,109 | 84.1 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr8:26,830,632–26,831,522 | 253.2 kb | Distal (>10kb) Multiome | 126 | |
| chr8:26,865,543–26,867,446 | 289.4 kb | Distal (>10kb) Multiome | 474 |
Genomic view of the DPYSL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.