This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DPP8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPP8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPP8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:65,286,029–65,287,330 | 230.8 kb | Distal (>10kb) Multiome | 919 | |
| chr15:65,295,595–65,297,682 | 221.4 kb | Distal (>10kb) Multiome | 1039 | |
| chr15:65,299,879–65,301,676 | 216.7 kb | Distal (>10kb) Multiome | 464 | |
| chr15:65,303,709–65,305,825 | 212.8 kb | Distal (>10kb) Multiome | 1230 | |
| chr15:65,355,116–65,356,095 | 162.1 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 139.7 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 131.9 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 116.3 kb | Distal (>10kb) Multiome | 406 | |
| chr15:65,414,873–65,415,582 | 102.4 kb | Distal (>10kb) Multiome | 333 | |
| chr15:65,421,061–65,422,050 | 96.2 kb | Distal (>10kb) Multiome | 457 | |
| chr15:65,422,462–65,423,579 | 94.6 kb | Distal (>10kb) Multiome | 450 | |
| chr15:65,517,110–65,517,892 | 46 bp | At TSS Multiome | 1031 | |
| chr15:65,521,411–65,521,886 | 3.9 kb | Proximal (<10kb) Multiome | 35 | |
| chr15:65,530,109–65,531,265 | 12.8 kb | Distal (>10kb) Multiome | 922 | |
| chr15:65,610,849–65,611,766 | 93.6 kb | Distal (>10kb) Multiome | 1108 | |
| chr15:65,791,540–65,792,954 | 274.6 kb | Distal (>10kb) Multiome | 949 |
Genomic view of the DPP8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.