DPM3

dolichyl-phosphate mannosyltransferase subunit 3, regulatory | MGC125904, MGC125905, MGC34275

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.2

Biological processes 16 terms

dolichol phosphate mannose biosynthetic process (GO:0180047)dolichol-phosphate-mannose synthase complex (GO:0033185)dolichol-phosphate-mannose synthase complex (GO:0033185)dolichyl monophosphate biosynthetic process (GO:0043048)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)enzyme activator activity (GO:0008047)glycoprotein biosynthetic process (GO:0009101)membrane (GO:0016020)protein O-linked glycosylation via mannose (GO:0035269)protein binding (GO:0005515)protein-membrane adaptor activity (GO:0043495)

Expression (TPM)

TFs regulating DPM3 0 TFs

Transcription factors with Perturb-seq knockdown data for DPM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DPM3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:154,870,031–154,870,680	270.2 kb	Distal (>10kb) Multiome	300
chr1:154,936,148–154,937,752	203.6 kb	Distal (>10kb) Multiome	1149
chr1:154,955,571–154,956,925	184.3 kb	Distal (>10kb) Multiome	504
chr1:154,961,269–154,962,529	178.8 kb	Distal (>10kb) Multiome	985
chr1:154,970,161–154,971,641	169.6 kb	Distal (>10kb) Multiome	535
chr1:154,972,362–154,975,914	165.9 kb	Distal (>10kb) Multiome	1085
chr1:154,982,968–154,983,632	157.3 kb	Distal (>10kb) Multiome	693
chr1:154,998,961–155,004,423	141.2 kb	Distal (>10kb) Multiome	1210
chr1:155,017,084–155,017,941	123.0 kb	Distal (>10kb) Multiome	1003
chr1:155,050,292–155,052,078	89.3 kb	Distal (>10kb) Multiome	948
chr1:155,061,415–155,064,552	76.6 kb	Distal (>10kb) Multiome	860
chr1:155,070,748–155,071,423	69.4 kb	Distal (>10kb) Multiome	542
chr1:155,078,524–155,079,535	61.7 kb	Distal (>10kb) Multiome	397
chr1:155,079,852–155,081,529	59.6 kb	Distal (>10kb) Multiome	539
chr1:155,084,373–155,086,501	55.5 kb	Distal (>10kb) Multiome	865
chr1:155,091,315–155,091,900	49.0 kb	Distal (>10kb) Multiome	594
chr1:155,126,247–155,126,903	14.1 kb	Distal (>10kb) Multiome	776
chr1:155,127,607–155,128,120	12.7 kb	Distal (>10kb) Multiome	578
chr1:155,135,100–155,136,750	4.7 kb	Proximal (<10kb) Multiome	938
chr1:155,140,438–155,140,694	at TSS	At TSS	618
chr1:155,166,847–155,168,170	27.3 kb	Distal (>10kb) Multiome	622
chr1:155,172,629–155,174,979	32.8 kb	Distal (>10kb) Multiome	903
chr1:155,192,921–155,194,099	53.1 kb	Distal (>10kb) Multiome	755
chr1:155,194,230–155,195,403	54.4 kb	Distal (>10kb) Multiome	753
chr1:155,196,127–155,196,592	55.9 kb	Distal (>10kb) Multiome	97
chr1:155,207,822–155,209,789	68.4 kb	Distal (>10kb) Multiome	826
chr1:155,226,522–155,227,197	86.0 kb	Distal (>10kb) Multiome	600
chr1:155,227,312–155,228,116	87.1 kb	Distal (>10kb) Multiome	688
chr1:155,244,103–155,245,349	104.2 kb	Distal (>10kb) Multiome	900
chr1:155,250,356–155,251,199	110.3 kb	Distal (>10kb) Multiome	605
chr1:155,255,032–155,255,921	115.0 kb	Distal (>10kb) Multiome	661
chr1:155,261,679–155,262,788	121.8 kb	Distal (>10kb) Multiome	921
chr1:155,272,928–155,274,098	133.0 kb	Distal (>10kb) Multiome	768
chr1:155,276,933–155,278,884	138.0 kb	Distal (>10kb) Multiome	749
chr1:155,308,291–155,309,348	168.2 kb	Distal (>10kb) Multiome	934
chr1:155,320,564–155,321,470	180.4 kb	Distal (>10kb) Multiome	341
chr1:155,322,680–155,325,643	183.8 kb	Distal (>10kb) Multiome	979

Genome Browser

Genomic view of the DPM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.