Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DPM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,699,155–127,699,632 | 238.4 kb | Distal (>10kb) Multiome | 440 | |
| chr9:127,715,013–127,716,345 | 222.0 kb | Distal (>10kb) Multiome | 735 | |
| chr9:127,734,444–127,735,606 | 202.6 kb | Distal (>10kb) Multiome | 836 | |
| chr9:127,741,739–127,743,092 | 195.0 kb | Distal (>10kb) Multiome HiCAR | 367 | |
| chr9:127,754,123–127,755,506 | 182.5 kb | Distal (>10kb) Multiome | 279 | |
| chr9:127,770,807–127,771,925 | 166.4 kb | Distal (>10kb) Multiome | 550 | |
| chr9:127,784,682–127,787,009 | 151.3 kb | Distal (>10kb) Multiome | 858 | |
| chr9:127,802,385–127,803,632 | 134.9 kb | Distal (>10kb) Multiome | 867 | |
| chr9:127,809,338–127,810,272 | 128.0 kb | Distal (>10kb) Multiome | 276 | |
| chr9:127,825,222–127,826,046 | 112.2 kb | Distal (>10kb) Multiome | 451 | |
| chr9:127,828,234–127,829,024 | 109.3 kb | Distal (>10kb) Multiome | 521 | |
| chr9:127,877,282–127,878,202 | 60.1 kb | Distal (>10kb) Multiome | 531 | |
| chr9:127,897,316–127,897,796 | 40.4 kb | Distal (>10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 38.2 kb | Distal (>10kb) Multiome | 630 | |
| chr9:127,916,386–127,917,505 | 20.7 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 10.3 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 7.1 kb | Proximal (<10kb) Multiome | 537 | |
| chr9:127,937,578–127,938,244 | 74 bp | At TSS Multiome | 674 | |
| chr9:127,942,843–127,943,061 | 5.0 kb | Proximal (<10kb) | 273 | |
| chr9:127,943,778–127,944,132 | 5.9 kb | Proximal (<10kb) | 363 | |
| chr9:127,955,445–127,955,915 | 17.7 kb | Distal (>10kb) Multiome | 540 | |
| chr9:127,980,172–127,981,966 | 43.3 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 96.0 kb | Distal (>10kb) Multiome HiCAR | 69 | |
| chr9:128,034,940–128,035,527 | 97.5 kb | Distal (>10kb) Multiome HiCAR | 480 | |
| chr9:128,066,577–128,068,774 | 129.5 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr9:128,097,872–128,098,910 | 160.6 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 180.0 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 190.4 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 222.3 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 253.8 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 266.5 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 281.1 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the DPM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.